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Seamless capsule

A new drug delivery system (DDS) technology that makes it smaller and easier to drink, while also allowing for an increase or adjustment of the active ingredient content.

As an innovator in soft capsule technology, we have pursued various formulations to enhance product value over many years, resulting in the birth of OptiGel Micro (seamless capsule). This is truly the crystallization of drug delivery system (DDS) technology that clears the challenges of formulation development, such as complex formulations, the formulation of poorly soluble compounds, and the pursuit of better bioavailability. OptiGel Micro (seamless capsule) forms spherical capsules using a manufacturing process that utilizes droplets from the laminar flow of coating liquid and fill liquid, unlike the rotary die method used for soft capsule formation. The capsule size ranges from 1 to 7 mm, allowing for the production of smaller capsules than traditional soft capsules. The excipients are made from the same materials as other gelatin capsule coatings and can accommodate a wide range of contents, just like other products.

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[Analysis Case] Three-Dimensional Structural Observation and Membrane Thickness Analysis of Seamless Capsules

Evaluation and analysis of seamless capsules is possible using X-ray CT.

A seamless capsule is a spherical capsule without seams that can contain powders or liquids and is used in pharmaceuticals, among other applications. In this case, the 3D structure of the seamless capsule was evaluated using X-ray CT. As a result, foreign substances were detected inside the membrane. Additionally, the membrane thickness distribution was visualized in 3D and represented as a histogram. By using X-ray CT in this way, it is possible to non-destructively evaluate the internal structure, investigate foreign substances, and assess membrane thickness distribution. Measurement method: X-ray CT Product field: Pharmaceuticals Analysis purpose: Structural evaluation, membrane thickness evaluation, product investigation For more details, please download the materials or contact us.

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  • Contract Analysis

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Morishita Jintan Co., Ltd. Seamless Capsule Technology Technical Introduction

From pharmaceuticals to food and industrial applications! The ever-evolving seamless capsule technology!

Morishita Jintan Co., Ltd.'s seamless capsule technology is our core technology that can encapsulate various substances such as powders, liquids, and microorganisms. The "seamless capsule" is different from soft capsules made by rotary methods; it is a capsule with no seams and a shape close to a perfect sphere. This capsule is produced using a technology uniquely established by our company based on the "liquid droplet method." By simultaneously discharging liquid coating material and contents from a concentric multi-nozzle, interfacial tension acts between the coating liquid and the content liquid, allowing the coating liquid to envelop the content liquid. We apply seamless capsules with 2-layer, 3-layer, and 4-layer structures for the encapsulation of hydrophilic liquids, lipophilic liquids, and powders (dispersions), and we have built a track record in various fields including food, supplements, cosmetics, and pharmaceuticals. 【Features】 ■ Excellent formulation accuracy ■ Adjustable particle size ranging from 0.5mm to 8mm ■ Multi-layer structure capsules capable of incorporating various functions and substances ■ Capable of encapsulating a wide variety of internal liquids ■ Capable of encapsulating microorganisms such as beneficial probiotics (as dispersions) *For more details, please refer to our catalog or feel free to contact us.

  • Contract manufacturing

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